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鼻用噴霧裝置幫助精神疾病患者改善其社交技巧

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To test the nasal spray device, scientists at the University of Oslo worked with Optinose, a Norwegian biotechnology company.

爲了測試鼻腔噴霧器的性能,來自奧斯陸大學的科學家和挪威生物科技公司Optinose一起進行了研究。

"The patient inserts the device into the mouth and into one nostril. The patient takes a deep breath, closes the lips around the mouthpiece, and exhales into the device. The airflow carries the drug particles deep into the nose."

"病人把噴霧器一端插入嘴裏,一端插入一個鼻孔中。然後深呼吸,閉上嘴,用嘴脣固定吹口,然後向內部吹氣。氣流就會把藥物帶入鼻子內部。"

This means the oxytocin can get into the central nervous system faster, making it more effective.

這意味着催產素可以更快的到達中樞神經系統,大大的提高了效率。

鼻用噴霧裝置幫助精神疾病患者改善其社交技巧

"A lot of mental illnesses are characterized by deficits in social dysfunction, such as autism and schizophrenia. But there aren't any actual treatments which specifically target social dysfunction. So oxytocin has actually generated a lot of interests in its potential to treat social dysfunction."

"社交方面存在缺陷是許多精神病,例如自閉症和精神分裂症的特徵。但是目前並沒有任何專門針對性治療社交缺陷的藥物。因此,催產素因其具有改善社交障礙的功效而引起了人們對它的極大興趣。"

Previous research shows that even with just a single dose of oxytocin, people are more likely to look directly at someone, rather than avoid their gaze.

以往的研究表明,即便是使用了一劑量的催產素,人們也更傾向於直視某人而非迴避別人的目光。

"And this is really important as most information, when it comes to how others are thinking and feeling, is transmitted through this eye region. So by improving gaze to the eye region, you improve your ability to understand how others are thinking and feeling."

"這是十分重要的。尤其是當試圖瞭解別人的想法和感受時,大多數的信息都是通過眼部交流來傳遞的。因此,當人們提高了眼神交流能力時,他們便能更好的瞭解對方的思維和感受。"

The scientists in Oslo showed volunteer patients photos of people's faces to see how they would react.

奧斯陸的科學家向志願患者展示了一些人類面部的照片,觀察他們的反應。

"Some of these faces were angry, some of them are happy or some of them had neutral expressions. And in our experiment, we asked people to write how angry or how happy these people were. In our experiment, we found that people who were administered a low dose of intranasal ocytocin rated the neutral faces as less angry, compared to when they were given the placebo spray."

"有些是憤怒的表情照,有些是高興的,還有些是自然的中性表情。實驗中,我們要求志願患者寫下這些表情照中人們的的憤怒或者高興的程度。通過實驗我們發現,那些注射了微量鼻內催產素的志願者會認爲那些中性表情圖片中人的生氣程度比較低。而與之相比,那些注射了無效對照劑的志願者則會認爲中性表情的人更加生氣。"

The team will be continuing the research by giving people with autism a low dose of ocytocin twice a day.

研究團隊會每天給那些自閉症患者注射兩次微量的催產素,以此繼續其研究。